Awareness of Parkinson’s disease, also known as parkinsonism grew once famous actor Michael J. Fox shared his diagnosis with the public in 1998. Fox was diagnosed with young-onset Parkinson’s disease back in 1991. To his credit, Michael J. Fox created The Michael J. Fox Foundation for Parkinson’s Research to find a cure. I am excited about this research study from Frontiers in Immunology “Cocoa and Dark Chocolate Polyphenols: From Biology To Clinical Applications” dated June 9th, 2017. Especially interested in the information applicable to Parkinson’s and Alzheimer’s patients. According to the research, they found “Beneficial effects of cocoa flavanols on the progression of Parkinson’s disease (PD) and Alzheimer’s disease (AD) “.
Inhibition of 5-S-cysteinil-dihydrobenzothiazine-mediated neuronal damage (110)
Activation of brain-derived neurotrophic factor on amyloid (A)β plaque-treated cells or on Aβ oligomer-treated cells (116)
Anti-inflammatory effect mediated by quercetin on glial cells, behaving as certain kinase inhibitors, thus preventing excitotoxic death in neurons (112, 113)
Activation of NAD(+)-dependent histone deacetylase enzymes known as sirtuins (118)
Reduction of hyperglycemia and cholinesterase activity in the hippocampus with improvement of cognitive functions (121)
“Conclusively, in the light of the above considerations, cocoa and dark chocolate-based diet may be beneficial in aged people for improvement of the neuro–cardiovascular connectivity.”
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Cocoa and Dark Chocolate Polyphenols: From Biology to Clinical Applications, Thea Magrone, Matteo Antonio Russo, Emilio Jirillo
Front Immunol. 2017; 8: 677. Published online 2017 Jun 9. doi: 10.3389/fimmu.2017.00677